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UF Health University of Florida
Weizhou Zhang Laboratory Department of Pathology, Immunology, and Laboratory Medicine
Maddy E Carelock

Maddy E Carelock

Postdoctoral Associate

Department: MD-NEUROLOGICAL SURGERY
Business Phone: (352) 273-9000
Business Email: madison.carelock@ufl.edu
CV: View Curriculum Vitae

On This Page

About Maddy E Carelock

I am currently a Postdoctoral Associate at the University of Florida, co-mentored by Drs. Weizhou Zhang and Elias Sayour. My research focuses broadly on drug development, translational immuno-oncology, and cancer therapeutics. I have expertise in PROTAC degrader technology and combinatorial immunotherapy strategies across multiple cancer models, including pancreatic and breast cancer.

My current work centers on the continued optimization and translational development of newly patented PROTAC compounds, while also leading projects aimed at expanding our lab’s mRNA cancer vaccine platform. These efforts include using machine learning–guided fate mapping of circulating tumor cells to better understand metastatic progression and therapeutic vulnerability. In parallel, I am involved in translational studies applying mRNA-based cancer vaccine strategies to squamous cell carcinomas in large aquatic animal models, including dolphins and sea turtles.

Beyond the bench, I am actively involved in several campus-wide educational and outreach initiatives, including the UF Health Cancer Center Ambassador Committee, as well as mentorship programs such as the Student Science Training Program and the University Scholars Program.

Please see my CV for additional information regarding my research experience, presentations, and funding history. I welcome questions and potential collaborations.

Accomplishments

  1. Established UFCOM’s 1st PhD White Coat Ceremony

    UF College of Medicine Graduate Program

  2. Predoctoral Award

    UF Health Cancer Center

  3. PhD Candidacy

    UF College of Medicine Graduate Program

  4. Predoctoral Fellow

    UF Health Cancer Center

  5. Grinter Scholar

    UF College of Medicine Graduate Program

  6. UFHCC Ambassadorship

    UF Health Cancer Center

Publications

Academic Articles

  1. PROTAC-mediated NR4A1 degradation as a novel strategy for cancer immunotherapy.

    Journal
    The Journal of experimental medicine.
    Volume/Issue
    221(3)
    [DOI]
    10.1084/jem.20231519.
    [PMID]
    38334978.
    22 citations PubMed Publisher’s Site

  2. Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy

    Journal
    Life Medicine.
    Volume/Issue
    2(3)
    [DOI]
    10.1093/lifemedi/lnad019.
    Publisher’s Site

  3. Breast Cancer Stem Cells: Signaling Pathways, Cellular Interactions, and Therapeutic Implications

    Journal
    Cancers.
    Volume/Issue
    14(13)
    [DOI]
    10.3390/cancers14133287.
    [PMID]
    35805056.
    29 citations PubMed Publisher’s Site

Education

  1. Postdoctoral Associate

    University of Florida

  2. PhD Graduate Student

    University of Florida College of Medicine

  3. Bachelor of Science in Biology. Concentration: Molecular Biology

    University of South Carolina Aiken

Contact Details

Phones:
Business:
(352) 273-9000
Emails:
Business:
madison.carelock@ufl.edu
Addresses:
Business Mailing:
PO Box 100265
Department of Neurosurgery
 GAINESVILLE FL 32610
Business Street:
1333 Center Dr
 GAINESVILLE FL 32608